normal limit for serum alanine aminotransferase level and distribution of metabolic factors in old population of kalaleh, iran

نویسندگان

ali kabir department of epidemiology, faculty of public health, shahid beheshti university of medical sciences, tehran, ir iran; center for educational research in medical sciences, tehran university of medical sciences, tehran, ir iran

akram pourshams digestive disease research center, shariati hospital, tehran university of medical sciences, tehran, ir iran. tel: +98-2182415104, fax: +98-2182415400 ; digestive disease research center, shariati hospital, tehran university of medical sciences, tehran, ir iran. tel: +98-2182415104, fax: +98-2182415400

masoud khoshnia golestan research center of gastroenterology and hepatology, golestan university of medical sciences, gorgan, ir iran

fatemeh malekzadeh digestive disease research center, shariati hospital, tehran university of medical sciences, tehran, ir iran. tel: +98-2182415104, fax: +98-2182415400

چکیده

backgrounds normal or elevated values of serum alanine aminotransferase level (alt) vary in different studies mostly related to characteristics of reference population including age, gender, body mass index, nonalcoholic fatty liver disease (nafld), and metabolic syndrome prevalence. objectives to measure upper normal limit (unl) for serum alt in an apparently healthy iranian old population (which we had not sufficient data before this study), and its modulating factors. patients and methods all inhabitants (> 50 years old) of kalaleh, golestan, iran (n = 1986) were invited to the study. alt measurements were performed for all subjects using the same laboratory method. upper limit of normal (uln) alt was calculated based on its 95th percentile in normal weight subjects. modulating factors of alt were determined by multivariate analysis. results a total of 1309 subjects, with the mean age of 61.5 ± 7.5 years were included. unl of alt was 18.8 u/l and 21.4 u/l in women and men, respectively. based on univariate analysis, waist circumference (r = 0.124, p = 0.01), body mass index (r = 0.118, p = 0.01), triglyceride (r = 0.143, p = 0.01), and having metabolic syndrome (or = 2.04) modulate alt levels in men. also triglyceride (r = 0.119, p = 0.01) modulates alt levels in women. conclusions the calculated level for unl of alt is considerably far lower than previous accepted value. age, gender, ethnicity, and metabolic factors should be accounted in future studies to determine normal alt level.

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Normal Limit for Serum Alanine Aminotransferase Level and Distribution of Metabolic Factors in Old Population of Kalaleh, Iran

BACKGROUNDS Normal or elevated values of serum alanine aminotransferase level (ALT) vary in different studies mostly related to characteristics of reference population including age, gender, body mass index, nonalcoholic fatty liver disease (NAFLD), and metabolic syndrome prevalence. OBJECTIVES To measure upper normal limit (UNL) for serum ALT in an apparently healthy Iranian old population (...

متن کامل

Re-evaluation of serum alanine aminotransferase upper normal limit and its modulating factors in a large-scale population study.

BACKGROUND The upper normal limit (ULN) of serum alanine-aminotrasferase (ALT) normal range was recently challenged, because patients diagnosed with liver diseases may have 'normal' or near-'normal' ALT levels, and because possible modulators are often ignored in determining normal range. AIM To estimate the ULN for serum ALT and to identify factors modulating it. SUBJECTS AND METHODS We re...

متن کامل

ec adoption and critical success factors of ec in smes in iran

تجارت الکترونیکی شیوه اجرای مسئولیتها، تقابل با مشتریان و امور معمول عملیاتی در شرکتها را تغییر داده است. تجارت الکترونیکی در عمل تنها خرید و فروش کالاها را از طریق ابزار الکترونیک نمی باشد، بلکه تمام فعالیتهای لازم جهت انجام فرایند فروش را نیز در بر میگیرد. در اواخر دهه 1990 بسیاری از شرکتها فعالیتهای خود را به منظور دستیابی به مشتریان جدید و یا ارائه فرصتهای جدید به مشتریان موجود گسترش دادند...

Upper limit of normal for alanine aminotransferase: quo vadis?

Several studies suggest that a substantial number of patients with normal serum alanine aminotransferase (ALT) levels, defined by current thresholds, have ongoing hepatic necro-inflammation and fibrosis, and are at risk of liver disease progression. A major problem lies in the definition of normality. The current upper limit of normal (ULN) for ALT was established in the 1980s when reference po...

متن کامل

Redefining the alanine aminotransferase upper limit of normal improves the prediction of metabolic syndrome risk.

BACKGROUND Multiple studies have recently proposed the lowering of upper limit of normal (ULN) for alanine aminotransferase (ALT) to improve the diagnostic sensitivity for viral hepatitides and metabolic syndrome (MS). We have tried to validate some of the proposed ULNs in the diagnosis of MS. METHODS We used data from the HepaMeta Study conducted in 2011 in Slovakia, which explored the preva...

متن کامل

Upper Limits of Normal for Serum Alanine Aminotransferase Levels in Chinese Han Population

BACKGROUND AND OBJECTIVES Serum alanine aminotransferase (ALT) activity is the most common tool for the assessment of liver diseases. However, it is not clear whether the current normal ALT range really discriminate patients with or without liver diseases. The present study was to establish a new normal range of ALT and examine its ability to identify patients with hepatitis B or nonalcoholic f...

متن کامل

منابع من

با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید


عنوان ژورنال:
hepatitis monthly

جلد ۱۳، شماره ۱۰، صفحات ۰-۰

میزبانی شده توسط پلتفرم ابری doprax.com

copyright © 2015-2023